منابع مشابه
Cyclophosphamide metabolism is affected by azole antifungals.
We performed a randomized trial to compare the safety and efficacy of itraconazole with fluconazole in preventing fungal infections in patients undergoing allogeneic stem cell transplantation (SCT). Itraconazole (intravenous 200 mg daily, or oral solution 2.5 mg/kg 3 times daily) and fluconazole (intravenous or oral, 400 mg daily) were administered with the start of conditioning therapy, until ...
متن کاملManagement of Drug-Drug Interaction between Everolimus and Azole Antifungals in a Cardiac Transplant Patient
A 64-year-old Caucasian male was admitted to the infectious disease department in May 2016 for exploration of a febrile syndrome lasting for two months associated with chronic cough for 1 year. He was treated by Everolimus (Certican®) 1 mg bid since 2011 as anti-rejection drug after cardiac transplantation in 1990. His treatment also included Atorvastatin 10mg/d, Ezetimibe 10mg/d, Prasugrel 10m...
متن کاملTrafficking through the late endosome significantly impacts Candida albicans tolerance of the azole antifungals.
The azole antifungals block ergosterol biosynthesis by inhibiting lanosterol demethylase (Erg11p). The resulting depletion of cellular ergosterol and the accumulation of "toxic" sterol intermediates are both thought to compromise plasma membrane function. However, the effects of ergosterol depletion upon the function of intracellular membranes and organelles are not well described. The purpose ...
متن کاملInhibition of mitochondrial function in isolated rate liver mitochondria by azole antifungals.
Ketoconazole is an imidazole oral antifungal agent with a broad spectrum of activity. Ketoconazole has been reported to cause liver damage, but the mechanism is unknown. However, ketoconazole and a related rug, miconazole, have been shown to have inhibitory effects on oxidative phosphorylation in fungi. Fluconazole, another orally administered antifungal azole, has also been reported to cause l...
متن کاملFactors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants.
The magnitude of drug interactions between azole antifungals and immunosuppressants is drug and patient specific and depends on the potency of the azole inhibitor involved, the resulting plasma concentrations of each drug, the drug formulation, and interpatient variability. Many factors contribute to variability in the magnitude and clinical significance of drug interactions between an immunosu...
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ژورنال
عنوان ژورنال: Pharmacology & Pharmacy
سال: 2013
ISSN: 2157-9423,2157-9431
DOI: 10.4236/pp.2013.43052